Vitamin K prescribing patterns and bone health surveillance in UK children with cystic fibrosis

Authors: Urquhart, D. S.1; Fitzpatrick, M.2; Cope, J.3; Jaffe, A.1

Source: Journal of Human Nutrition & Dietetics, Volume 20, Number 6, December 2007 , pp. 605-610(6)

Publisher: Wiley-Blackwell

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Abstract Background 

Bone disease has become an increasingly recognized complication of cystic fibrosis (CF). Although causes of CF bone disease are multifactorial, there has been recent interest in the role of vitamin K in CF bone disease. Aims and methods 

A questionnaire survey of all UK paediatric CF centre dietitians and centre directors was carried out to ascertain current practice with regard to vitamin K prescribing and bone health surveillance. Results 

The survey had a 97% response rate representing 3414 CF children. Twenty-three centre directors and 19 dietitians responded, and at least moderate agreement was noted with kappa scores >0.41 for all but one question assessed. Ninety-three per cent centres report that >90% pancreatic insufficient patients receive vitamins A, D and E, yet only 18% centres routinely supplement vitamin K. The majority (60%) report that <10% of their CF patients receive vitamin K, whilst vitamin K dosage varied from 0.3–0.5 to 10 mg day−1. Only one centre undertook no bone health surveillance, and vitamin D levels are measured in 89%, calcium intake assessed in 82% and dual-energy X-ray absorptiometry scans performed in 61% centres. Discussion 

Heterogeneity in both vitamin K prescribing practices and bone health surveillance in CF across the UK were noted, underlining the need for a national consensus on bone health management, as well as acting as a call for longitudinal research into the clinical effectiveness of vitamin K therapy in CF.

Keywords: bone health; cystic fibrosis; vitamin K

Document Type: Research Article


Affiliations: 1: Portex Respiratory and Anaesthesia Unit, Institute of Child Health, London, UK 2: Departments of Nutrition and Dietetics 3: Pharmacy, Great Ormond Street Hospital, London, UK

Publication date: December 1, 2007

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