Intolerance to an extensively hydrolysed formula mistaken for postoperative diarrhoea in a child with neuroblastoma
Authors: Ward, E.; Picton, S.
Source: Journal of Human Nutrition & Dietetics, Volume 14, Number 2, April 2001 , pp. 149-152(4)
Persistent diarrhoea has recently been reported as a common problem following surgical resection for advanced abdominal neuroblastoma.Case study
A 10-month-old child, who had previously had no nutritional problems whilst undergoing chemotherapy treatment for a stage IV neuroblastoma, developed severe diarrhoea following tumour resection. He required nutritional support and was commenced on a continuous overnight nasogastric feed of a non-milk protein hydrolysate feed (MCT Pepdite 0-2, S.H.S. International Ltd, UK) His diarrhoea persisted and it was assumed that this was a postoperative problem which in time would regress. Two months later the child was admitted with a rectal prolapse, and a colonoscopy and biopsy suggested allergic protocolitis. The diarrhoea resolved rapidly on stopping the feed.Conclusion
Although he was never re-challenged with the non-milk protein hydrolysate, it appears that he had a rare intolerance to an extensively hydrolysed protein formula which was masked by the assumption that his diarrhoea was a postoperative problem.
Document Type: Miscellaneous
Publication date: April 1, 2001