@article {Leonard:1998:0952-3871:493,
	author = "Leonard C.H. and Ross-Wilson C. and Smyth A.R. and Polnay J. and Range S.P. and Knox A.J.",
	title = "A study of a single high potency multivitamin preparation in the management of cystic fibrosis",
	journal = "Journal of Human Nutrition & Dietetics",
	volume = "11",
	number = "6",
	year = "1998",
	abstract = "<P><I>Background: </I>ADEKs? is a new multivitamin preparation formulated specifically for cystic fibrosis (CF) patients, containing all four fat-soluble vitamins. There is no data currently available on its use in CF. <I>Method: </I>We carried out a retrospective study to evaluate ADEKs? in 54 CF patients attending the specialist CF Unit at Nottingham City Hospital. Plasma vitamin A and E levels were collected from annual review reports when taking ADEKs? and a year previously when using other vitamin preparations. Dietary assessment data was available for 24 of these patients (11 children, 13 adults). <I>Results: </I>ADEKs? was taken for a median of 9.5 months by 19 children (mean age 11.3 years; range 7-15 years) and for 4 months by 35 adults (mean age 24 years; range 17-36 years). Median plasma vitamin A levels were significantly higher (<I>P</I>&lt;0.05) for all age groups (27% increase for 7-10 year olds, 48% increase for 11-15 year olds, 100% increase for 16+ year olds) following the change from other vitamin supplements to ADEKs?. Median plasma vitamin E levels were also significantly higher (59% increase for 7-10 year olds; 16% increase for 11-15 year olds; 26% increase for 16+ year olds). Fifteen (28%) and 9 (17%) patients went from below to within the normal plasma reference range for vitamins A and E, respectively, when changed onto ADEKs?. Four (7%) and 11 (20%) patients had values above the normal plasma range for vitamins A and E, respectively, whilst on ADEKs?. <I>Conclusion: </I>This study suggests that ADEKs? tablets are useful for CF patients aged over 10 years as plasma vitamin A and E levels were improved. The use of a single vitamin preparation such as ADEKs? is likely to improve compliance. We have reservations over its use amongst the 7-10 year olds because of high plasma vitamin A (3/9) and E (7/9) levels, although further research may ultimately endorse its future use within this group.</P>",
	pages = "493-500",
	url = "http://www.ingentaconnect.com/content/bsc/jhnd/1998/00000011/00000006/art00118",
	keyword = "ADEKs?, cystic fibrosis, fat-soluble vitamins"
}