A study of a single high potency multivitamin preparation in the management of cystic fibrosis

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Background: ADEKs® is a new multivitamin preparation formulated specifically for cystic fibrosis (CF) patients, containing all four fat-soluble vitamins. There is no data currently available on its use in CF. Method: We carried out a retrospective study to evaluate ADEKs® in 54 CF patients attending the specialist CF Unit at Nottingham City Hospital. Plasma vitamin A and E levels were collected from annual review reports when taking ADEKs® and a year previously when using other vitamin preparations. Dietary assessment data was available for 24 of these patients (11 children, 13 adults). Results: ADEKs® was taken for a median of 9.5 months by 19 children (mean age 11.3 years; range 7-15 years) and for 4 months by 35 adults (mean age 24 years; range 17-36 years). Median plasma vitamin A levels were significantly higher (P<0.05) for all age groups (27% increase for 7-10 year olds, 48% increase for 11-15 year olds, 100% increase for 16+ year olds) following the change from other vitamin supplements to ADEKs®. Median plasma vitamin E levels were also significantly higher (59% increase for 7-10 year olds; 16% increase for 11-15 year olds; 26% increase for 16+ year olds). Fifteen (28%) and 9 (17%) patients went from below to within the normal plasma reference range for vitamins A and E, respectively, when changed onto ADEKs®. Four (7%) and 11 (20%) patients had values above the normal plasma range for vitamins A and E, respectively, whilst on ADEKs®. Conclusion: This study suggests that ADEKs® tablets are useful for CF patients aged over 10 years as plasma vitamin A and E levels were improved. The use of a single vitamin preparation such as ADEKs® is likely to improve compliance. We have reservations over its use amongst the 7-10 year olds because of high plasma vitamin A (3/9) and E (7/9) levels, although further research may ultimately endorse its future use within this group.

Keywords: ADEKsý; cystic fibrosis; fat-soluble vitamins

Document Type: Research Article

Affiliations: 1: Department of Dietetics & Nutrition, Nottingham City Hospital NHS Trust, Nottingham, UK 2: Department of Paediatrics, Nottingham City Hospital NHS Trust, Nottingham, UK 3: Department of Respiratory Medicine, Nottingham City Hospital NHS Trust, Nottingham, UK

Publication date: December 1, 1998

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