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Moderate amounts of n-3 fatty acid enriched seafood products are effective in lowering serum triglycerides and blood pressure in healthy subjects

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A double-blind cross-over study was conducted during two 3-week periods. Two series of seafood products were prepared, one containing n-3 fatty acids derived from fish oil triglyceride concentrate and one containing n-6 rich sunflower oil in identical amounts. These products were added to the subjects» ordinary diet. After a wash-out period of at least 4 weeks they switched over to the other diet. Twenty-three subjects with borderline high blood lipids participated, five women and 19 men, with a mean age of 48±9 years. The inclusion of the n-3 enriched seafood products in the diet caused significant reductions of serum triglycerides (25%) and of the systolic blood pressure of 3.7%. An increase in the proportion of long-chain fatty acids in the serum phospholipids after the fish oil period was pronounced. Positive effects were seen on insulin and free fatty acid concentrations with a reduction of 37% of free fatty acids on the fish oil period and of 18.6% of serum insulin concentration. An increase of malondialdehyde concentration in plasma by 21% was seen during the fish oil period. The positive effects on the serum triglyceride and blood pressure are interesting from the viewpoint of public health with regard to the risk of the cardiovascular disease.

Document Type: Research Article


Affiliations: 1: Unit for Clinical Nutrition Research, Department of Geriatrics, Uppsala University, Sweden 2: Swedish Institute for Food Research, Gothenburg, Sweden

Publication date: 1996-04-01

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