Associations Between Polymorphisms of the High-Affinity Immunoglobulin E Receptor and Late-Onset Airflow Obstruction in Older Populations
To test the hypothesis that genetic polymorphisms in the subunit of the high-affinity immunoglobulin E (IgE) receptor are associated with late-onset airflow obstruction. Design:
Case-control candidate gene association study. Setting:
Department of Medicine for the Elderly and Respiratory Medicine in three teaching hospitals in Leicester and Manchester, United Kingdom. Participants:
Cases with late-onset airflow obstruction with age-, sex-, and geographically matched controls. Measurements:
Subjects were genotyped for two polymorphisms of the subunit of the high-affinity IgE receptor (RsaI intron 2 and RsaI exon 7). The association between the polymorphisms and phenotypes was examined using contingency tables and linear regression models. Results:
Two hundred eighty-three cases and 144 controls were genotyped. RsaI exon 7 AA was associated with eczema (odds ratio (OR)=2.27, 95% confidence interval (CI)=1.17–4.38, P=.015). No other associations were found. Total serum IgE levels were significantly higher in cases than controls (adjusted OR for high/low IgE=2.56, 95% CI=1.53–4.28, P<.001). Conclusion:
Serum IgE levels, but not the high-affinity IgE receptor polymorphisms, were associated with late-onset airflow obstruction, suggesting that interaction between environmental and genetic factors controlling serum IgE levels and disease pathogenesis may differ between early- and late-onset airflow obstruction phenotypes.
Document Type: Research Article
Affiliations: 1: Institute for Lung Health and †Institute of Genetics, University of Leicester, Leicester, United Kingdom; 2: Department of Medicine for the Elderly, University of Manchester, Manchester, United Kingdom; and 3: Sheffield Institute for Studies on Aging, University of Sheffield, Sheffield, United Kingdom.
Publication date: 2003-09-01