Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: Frequency and predictors

Authors: Sachdeva, Sanjeev; Rawat, Ajit Kumar; Reddy, Ravi Sankar; Puri, Amarender Singh

Source: Journal of Gastroenterology and Hepatology, Volume 26, Supplement 3, April 2011 , pp. 135-138(4)

Publisher: Wiley-Blackwell

Abstract:

Objective and Background: 

Small intestinal bacterial overgrowth (SIBO) has been implicated in pathogenesis of IBS. We aimed to study frequency and predictors of SIBO in patients with IBS. Methodology: 

We included 59 consecutive patients of IBS & 37 healthy controls (HC). Evaluation for SIBO was done by glucose breath test (GBT) using 100 gm of glucose after an overnight fast. Breath hydrogen & methane concentration were noted at baseline & every 15 min after administration of glucose for a total of 3 h. Persistent rise in breath hydrogen or methane > 12 ppm above basal was considered diagnostic of SIBO. Results: 

Of 59 patients, 27 were diarrhoea predominant (D-IBS), 11 were constipation predominant (C-IBS) and 21 were mixed type (M-IBS). Median age of patients (34 [18-47] years) were comparable to controls (35 [20-48] years) (P = 0.21). Patient group was similar to HC in gender distribution (male 41/59 [69.5%]vs 25/37 [67.6%], P = 0.36). SIBO was more frequent in patients with IBS than HC (14/59 [23.7%]vs 1/37 [2.7%], P = 0.008). Patients with D-IBS more often had SIBO as compared to non-D-IBS (10/27 [37%]vs 4/32 [12.5%], P = 0.02). C-IBS had lowest frequency of SIBO (1/11 [9%]) among all IBS subgroups. Patients with history of bloating more often had SIBO as compared to those without this symptom (11/23 [47.8%]vs 3/36 [8.3%], P = 0.002). Among IBS patients, females more often had SIBO as compared to males (8/18 [44.4%]vs 6/41 [14.6%], P = 0.01). Conclusions: 

SIBO was more frequent in patients with IBS as compared to healthy controls. D-IBS subtype, female gender & bloating were predictors of SIBO in patients with IBS.

Keywords: frequency; GBT; IBS; predictors; SIBO

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1746.2011.06654.x

Publication date: 2011-04-01

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