Decreased oxidation susceptibility of plasma low density lipoproteins in patients with Gilbert's syndrome

Authors: Yesilova, Zeki; Serdar, Muhittin; Ercin, C Nuri¹; Gunay, Alp²; Kilciler, Guldem¹; Hasimi, Adnan³; Uygun, Ahmet¹; Kurt, İsmail³; Erbil, M Kemal³; Dagalp, Kemal¹

Source: Journal of Gastroenterology and Hepatology, Volume 23, Number 10, October 2008 , pp. 1556-1560(5)

Publisher: Wiley-Blackwell

Abstract:

Background and Aim: 

The association of hyperbilirubinemia in Gilbert's syndrome (GS) with a decrease in prevalence of coronary artery disease is a well-known phenomenon. In this study, the state of low-density lipoprotein (LDL) oxidation which has been postulated to be a significant determinant at the etiopathogenesis of atherosclerotic disorders was investigated among individuals with GS. Methods: 

For this purpose, serum cholesterol, LDL cholesterol, high-density lipoprotein cholesterol, triglycerides, uric acid, apolipoprotein A and B, bilirubins, thiobarbituric acid-reactive substances, and the sensitivity of LDL oxidation levels, as well as serum alanine aminotransferase, aspartate aminotranserfase, gamma glutamil transferase, and alkaline phosphatase activities, were determined in 17 patients with Gilbert's syndrome and 15 healthy adults. Results: 

There was no significant difference between the groups except the indirect bilirubin parameter (P < 0.001). In comparison with the healthy individuals, LDL oxidation levels between 75 and 120 min were significantly lower (P < 0.005) along with prolonged lag-phase in GS patients, indicating a delay in oxidation susceptibility. Conclusion: 

It is suggested that the chronic hyperbilirubinemia leading to a lag-phase prolongation in LDL oxidation and a decrease in LDL oxidation may be reason for the low percentage of coronary artery disease.

Keywords: bilirubin; Gilbert's syndrome; low-density lipoprotein (LDL) oxidation

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1746.2008.05388.x

Affiliations: 1: Departments of Gastroenterology, 2: Department of Gastroenterology, Golcuk Naval Hospital, Golcuk, Kocaeli, Turkey 3: Clinical Biochemistry, Gülhane Military Medical School, Ankara, and

Publication date: 2008-10-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Gastroenterology
• By this author: Yesilova, Zeki ;  Serdar, Muhittin ;  Ercin, C Nuri ;  Gunay, Alp ;  Kilciler, Guldem ;  Hasimi, Adnan ;  Uygun, Ahmet ;  Kurt, İsmail ;  Erbil, M Kemal ;  Dagalp, Kemal

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers