Bacterial translocation: Overview of mechanisms and clinical impact

Authors: Balzan, Silvio; de Almeida Quadros, Claudio; de Cleva, Roberto; Zilberstein, Bruno; Cecconello, Ivan

Source: Journal of Gastroenterology and Hepatology, Volume 22, Number 4, April 2007 , pp. 464-471(8)

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Abstract:

Bacterial translocation (BT) is a phenomenon in which live bacteria or its products cross the intestinal barrier. Gut translocation of bacteria has been shown in both animal and human studies. BT and its complications have been shown clearly to occur in animal models, but its existence and importance in humans has been difficult to ascertain. We review the mechanisms of BT and its clinical impact based on the current literature.

Keywords: acute pancreatitis; bacterial translocation; cirrhosis; gut barrier; multiple organ dysfunction syndrome; systemic inflammatory response syndrome

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1746.2007.04933.x

Publication date: 2007-04-01