IngentaConnect Low-dose rabeprazole, amoxicillin and metronidazole triple therap...

Authors: WONG, WAI MAN¹; HUANG, JIAQING¹; XIA, HARRY HX¹; FUNG, FIONA MY¹; TONG, TERESA SM¹; CHEUNG, KESS L¹; HO, VICKY YK¹; LAI, KAM CHUEN¹; CHAN, CHI KUEN¹; CHAN, ANNIE OO¹; HUI, CHEE-KIN¹; LAM, SHIU KUM¹; WONG, BENJAMIN CY

Source: Journal of Gastroenterology and Hepatology, Volume 20, Number 6, June 2005 , pp. 935-940(6)

Publisher: Blackwell Publishing

Abstract:

Background:

Rabeprazole in combination with amoxicillin and metronidazole (RAM) has been shown to be an effective second-line treatment of Helicobacter pylori infection. The effects were compared of 7-day low-dose and high dose rabeprazole in RAM for the primary treatment of H. pylori infection in Chinese patients. Methods:

Helicobacter pylori-positive dyspeptic patients were randomized to receive either (i) rabeprazole 10 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-10) or (ii) high-dose rabeprazole 20 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-20), each given twice daily for 7 days. Helicobacter pylori eradication was confirmed by ¹³C-urea breath test 5 weeks after stopping medications. Side-effects of treatments were documented. Results:

A total of 120 patients were eligible for analysis. By intention-to-treat and per-protocol analysis, the eradication rates were 83% and 86% in the RAM-10 group and 75% and 76% in the RAM-20 group, respectively (P = 0.26 and P = 0.17). Both regimens were well-tolerated and compliance was >98% in both groups. Conclusions:

Low-dose rabeprazole in combination with amoxicillin and metronidazole is an effective, economical and well-tolerated therapy for the treatment of H. pylori infection in Chinese population.

Keywords: amoxicillin; eradication; Helicobacter pylori; metronidazole; rabeprazole

Document Type: Research article

DOI: 10.1111/j.1440-1746.2005.03889.x

Affiliations: 1: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong

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Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients