Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients

Authors: WONG, WAI MAN; HUANG, JIAQING; XIA, HARRY HX; FUNG, FIONA MY; TONG, TERESA SM; CHEUNG, KESS L; HO, VICKY YK; LAI, KAM CHUEN; CHAN, CHI KUEN; CHAN, ANNIE OO; HUI, CHEE-KIN; LAM, SHIU KUM; WONG, BENJAMIN CY

Source: Journal of Gastroenterology and Hepatology, Volume 20, Number 6, June 2005 , pp. 935-940(6)

Publisher: Wiley-Blackwell

Abstract:

Background: 

Rabeprazole in combination with amoxicillin and metronidazole (RAM) has been shown to  be  an  effective  second-line  treatment  of Helicobacter  pylori  infection.  The  effects  were  compared of 7-day low-dose and high dose rabeprazole in RAM for the primary treatment of H. pylori infection in Chinese patients. Methods: 

Helicobacter pylori-positive dyspeptic patients were randomized to receive either (i) rabeprazole 10 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-10) or (ii) high-dose rabeprazole 20 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-20), each given twice daily for 7 days. Helicobacter pylori eradication was confirmed by ¹³C-urea breath test 5 weeks after stopping medications. Side-effects of treatments were documented. Results: 

A total of 120 patients were eligible for analysis. By intention-to-treat and per-protocol analysis, the eradication rates were 83% and 86% in the RAM-10 group and 75% and 76% in the RAM-20 group, respectively (P = 0.26 and P = 0.17). Both regimens were well-tolerated and compliance was >98% in both groups. Conclusions: 

Low-dose rabeprazole in combination with amoxicillin and metronidazole is an effective, economical and well-tolerated therapy for the treatment of H. pylori infection in Chinese population.

Keywords: amoxicillin; eradication; Helicobacter pylori; metronidazole; rabeprazole

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1746.2005.03889.x

Affiliations: 1: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong

Publication date: 2005-06-01

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• By this author: WONG, WAI MAN ;  HUANG, JIAQING ;  XIA, HARRY HX ;  FUNG, FIONA MY ;  TONG, TERESA SM ;  CHEUNG, KESS L ;  HO, VICKY YK ;  LAI, KAM CHUEN ;  CHAN, CHI KUEN ;  CHAN, ANNIE OO ;  HUI, CHEE-KIN ;  LAM, SHIU KUM ;  WONG, BENJAMIN CY

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