Skip to main content

Isolation and Identification of Three By-products Found in Methylamphetamine Synthesized by the Emde Route

Buy Article:

$43.00 plus tax (Refund Policy)


This article describes the isolation and structural elucidation of three compounds produced during the synthesis of methylamphetamine by the so-called “Emde” procedure. The “Emde” procedure involves the preparation of the intermediate chloropseudoephedrine or chloroephedrine from ephedrine or pseudoephedrine, respectively. The intermediates are then reduced to methylamphetamine with hydrogen under pressure in the presence of a catalyst. The by-product compounds were isolated from methylamphetamine by column chromatography and liquid chromatography (LC). Proton nuclear magnetic resonance spectroscopy (1H NMR), carbon nuclear magnetic resonance spectroscopy (13C NMR), and nanospray quadrupole-time of flight-mass spectrometry (Q-TOF-MS) were used to identify them as two stereoisomers of the compound N, N′-dimethyl-3,4-diphenylhexane-2,5-diamine and N-methyl-1-{4-[2-(methylamino)propyl]phenyl}-1-phenylpropan-2-amine.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Emde reaction; N; N-methyl-1-{4-2-(methylamino)propylphenyl}-1-phenylpropan-2-amine; N′-dimethyl-3,4-diphenylhexane-2,5-diamine; chemical profiling; forensic science; methylamphetamine

Document Type: Research Article

Affiliations: 1: National Measurement Institute, 1 Suakin St, Pymble, NSW, Australia. 2: School of Chemistry, University of Sydney, NSW, Australia.

Publication date: 2010-05-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more