Curcumin and its derivatives prevent hepatocyte lipid peroxidation in Anabas testudineus

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Abstract:

The present study evaluated the effect of five different curcuminoids, CURI, CURII, CURIII, a mixture of the three and a synthetic, curcumin–boron–oxalic acid complex, on Anabas testudineus hepatocyte lipid peroxidation after 30–60 min of incubation. The results showed that curcumin had a protective role as a strong antioxidant in teleosts. All the curcuminoids decreased the peroxidation products formed, with or without stimulating the antioxidant enzyme pathway. This suggests a direct reactive oxygen-species scavenging ability of curcuminoids. Their antioxidant effects appear to be time and dose-dependent.

Keywords: Anabas testudineus; antioxidants; curcuminoids; lipid peroxidation; liver

Document Type: Regular Paper

DOI: http://dx.doi.org/10.1111/j.1095-8649.2008.02044.x

Affiliations: 1: Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India 2: Department of Chemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India

Publication date: November 1, 2008

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