Healing of skin wounds in the African catfish Clarias gariepinus

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Abstract:

The African catfish Clarias gariepinus was used as a model for wound healing and tissue regeneration in a scale-less fish. A temporal framework of histological and cell proliferation markers was established after wound induction in the dorsolateral cranial region, by removing the epidermal and dermal layers, including stratum adiposum (SA). Wound closure and epidermis formation was initiated within 3 h post-procedure (hpp) with migration and concomitant proliferation of epidermal cells from the wound borders. The wound was covered by this primary epidermal front 12 hpp and fusion of the opposing epidermal fronts occurred within 24 hpp. Attachment of the newly formed epidermal layer to the underlying dermis was observed 48 hpp concomitant with a second wave of cell proliferation at the wound edge. Normal epidermal thickness within the wound was achieved 72 hpp. Formation of a basement membrane occurred by 120 hpp with concomitant emergence of the SA from the wound borders. Wound healing in C. gariepinus skin involved closure of the wound and re-epithelization through cell migration with a single wave of early cell proliferation not documented in other species. Furthermore, covering of the wound by epithelium as well as the reappearance of the basement membrane and SA occurred sooner than in other fish species.

Keywords: cicatrization; regeneration; tegument; teleost; wound healing

Document Type: Regular Paper

DOI: http://dx.doi.org/10.1111/j.1095-8649.2008.01950.x

Affiliations: 1: FZEA-USP, Basic Sciences Department, av. Duque de Caxias Norte, 225, 13635-900, Pirassununga, SP, Brazil 2: CEPTA-IBAMA, r. Prefeito Nemesio Pereira de Godoy, Km 6.5, 13630-970, Pirassununga, SP, Brazil 3: ICB-USP, Cell and Developmental Biology Department, rua Prof. Dr. Lineu Prestes, 1524, 005508-900, São Paulo, SP, Brazil 4: FMVZ-USP, Surgery Department, rua Prof. Dr. Orlando Marquez de Paiva, 87, 05508-900, São Paulo, SP, Brazil

Publication date: August 1, 2008

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