Skip to main content

Liver histopathology and accumulation of melano-macrophage centres in Hoplias malabaricus after long-term food deprivation and re-feeding

Buy Article:

$43.00 plus tax (Refund Policy)

In the Neotropical traíra Hoplias malabaricus, hepatocyte surface area declined after 30 days of fasting due to reserve utilization. Changes in normal organization of liver were not confirmed until 180 days of fasting. Severe histopathological changes occurred after 240 days. Pigment accumulation in the hepatocytes and increase in number and size (surface area) of melano-macrophage centres (MMC) were also verified during long-term food deprivation. The melano-macrophages were rich in ferric compounds, probably haemosiderin. This suggests that the activity of hepatic macrophages is related to the intense erythrocyte degradation that occurred in traíra following long-term food deprivation. After re-feeding for 30 days, the liver presented a partial restoration, but the large MMC remained. When compared to the respective starved group, the hepatocytes of re-fed fish increased in size, revealing recovering cell activity and storage of some energy reserves.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: fresh water; histology; lesion index; starvation; traíra

Document Type: Regular Paper

Affiliations: 1: Department of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil 2: Department of Physiological Sciences, Federal University of São Carlos, São Carlos SP, Brazil

Publication date: 2007-11-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more