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Characterization of TCDD‐induced craniofacial malformations and retardation of zebrafish growth

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The documented 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)‐induced effects on zebrafish Danio rerio including craniofacial malformations and a general retardation of growth, were further characterized in the present study. A significant decrease in total body length and the length of each bone in the upper and lower jaw was identified in exposed larvae from an exposure concentration of 30 ng l−1 TCDD. This study is the first quantitative evidence for the effects of TCDD on the upper jaw and also demonstrates that TCDD‐induced craniofacial malformations and retardation of growth are very sensitive endpoints of dioxin toxicity.

Keywords: TCDD; craniofacial; embryo; jaw; length; zebrafish

Document Type: Regular Paper

DOI: http://dx.doi.org/10.1111/j.1095-8649.2004.0352.x

Affiliations: 1: Toxico-Pathology Research Group, Department of Medicine, Human Anatomy and Cell Biology Building, University of Liverpool L69 3PX, U.K. and 2: Laboratory for Environmental Gene Regulation, Derby Building, University of Liverpool, Brownlow Street, Liverpool, Merseyside L69 3GS, U.K.

Publication date: April 1, 2004

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