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Treatment with an aromatase inhibitor suppresses high‐temperature feminization of genetic male (YY) Nile tilapia

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High temperature (36° C) treatment during sexual differentiation caused significant changes in sex ratio in YY male Nile tilapia Oreochromis niloticus fry (64.5% males compared to 100.0% males at 28° C), while dietary treatment with a chemical aromatase inhibitor (AI: Fadrozole™ CGS16949A) during this period suppressed the high temperature feminization (98.9% males). This implies that cytochrome P450 aromatase is mechanistically associated with temperature‐dependent sex determination (TSD) in this species. XY male fry did not show significant sex reversal at 36° C. In XX female fry, high temperature treatment resulted in significant masculinization (62.5% males compared with 21.9% males at 28° C), while treatment with AI at either temperature resulted in very high proportions of males (100.0% males at 36° C; 99.0% males at 28° C). These results confirm the importance of aromatase in sexual differentiation in the Nile tilapia below the TSD threshold and suggest that it also plays a role in TSD, at least in the YY genotype.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1095-8649.2002.tb01689.x

Affiliations: Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, U.K.

Publication date: March 1, 2002

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