IngentaConnect Autologous suction blister grafting for chronic leg ulcers

Authors: Costanzo, U; Streit, M; Braathen, LR

Source: Journal of the European Academy of Dermatology & Venereology, Volume 22, Number 1, January 2008 , pp. 7-10(4)

Publisher: Blackwell Publishing

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Abstract:

Background

Non-healing leg ulcers represent a treatment problem. Objective

Investigate grafting of autologous suction blister roofs as treatment. Methods

Twenty-nine chronic, non-healing leg ulcers of various aetiologies in 18 inpatients were treated by autologous epidermal grafting using the roofs of suction blisters. Results

55% of ulcers completely healed 2 to 6 weeks after grafting. A 50-90% reduction in size was documented in 34% and no change was observed in 11% of ulcers. Twelve weeks after grafting, 89% of ulcers were healed completely. In most ulcers, we observed a stimulation of reepithelialization from the wound edge (`edge effect') and an accelerated formation of healthy granulation tissue. During a follow-up period of 12 months, 90% of the ulcers remained healed. Conclusion

Grafting of autologous suction blister roofs is an effective treatment option for non-healing leg ulcers. The advantages of the method are its lack of pain, low costs and immediate availability.

Keywords: autologous; graft; leg ulcer; suction blister; wound healing

Document Type: Research article

DOI: 10.1111/j.1468-3083.2007.02148.x