Evaluation of the effect of Dardia® Lipo Line on skin inflammation induced by surfactants using the repeated open-application test

Authors: Ortonne, J-P; Queille-Roussel, C

Source: Journal of the European Academy of Dermatology & Venereology, Volume 21, Supplement 2, September 2007 , pp. 19-25(7)

Publisher: Wiley-Blackwell

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Abstract:

Background

Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin. Aim

To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin. Design and methods

Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6. Results

On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated. Conclusions

Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.

Keywords: Dardia; dry skin; hydration; irritation; sensitive

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1468-3083.2007.02383.x

Publication date: 2007-09-01

Evaluation of the effect of Dardia® Lipo Line on skin inflammation induced by surfactants using the repeated open-application test

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