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Fas (CD95) and bcl-2 expression in active skin lesions of Behçet's disease
Authors: Bari
, YS; Yildiz, L1; 
entürk, N2; Kandem
r, B1
Source: Journal of the European Academy of Dermatology & Venereology, Volume 19, Number 5, September 2005 , pp. 569-572(4)
Publisher: Wiley-Blackwell
Abstract:
Over-expression of bcl-2 in lymphocytes has an important role in some immunological and inflammatory diseases. Fas (CD95) is a cell surface molecule that mediates receptor-triggered apoptosis in various cells including autoreactive T cells. In this study we investigated bcl-2 and Fas (CD95) expression in dermal lymphocytes in active skin lesions of Behçet's disease (BD) and in skin biopsy samples with chronic, non-specific inflammations. Tissue sections of 29 skin lesions of Behçet's disease and of 10 chronic non-spesific inflammatory process cases from the archives of the Ondokuz Mays University's Pathology Department were immunohistochemically stained for bcl-2 and Fas (CD95), and lymphocytes in the dermal infiltrate were evaluated for cytoplasmic staining. bcl-2 staining was observed in the skin lesions of 22 cases (75.8%) of Behçet's disease. bcl-2 staining was detected in two (20%) control skin biopsy samples with non-specific chronic inflammation. Fas (CD95) positivity was not detected in lymphocytes in Behçet's disease-related skin lesions. Fas (CD95) staining was observed in only three skin biopsy samples with non-specific chronic inflammation. bcl-2 and Fas (CD95) staining values in Behçet's and non-specific inflammation groups were significantly different (P < 0.01); differences in the bcl-2 staining values between Behçet's patients with mucocutaneous involvement only and mucocutaneous and other systemic involvements were not significant (P > 0.05). Expression of bcl-2 and loss of Fas (CD95) expression in dermal lymphocytes may play a role in the development of skin lesions and may account for the chronic course with periodic exacerbations in BD.
Keywords: bcl-2; Behçet's disease; CD95; Fas
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1468-3083.2005.01250.x
Affiliations:
1:
Departments of Pathology
2:
Dermatology, Ondokuz Mays University, School of Medicine, Kurupelit/Samsun, Turkey.s University, School of Medicine, Kurupelit/Samsun, Turkey.">
Publication date: 2005-09-01
- In this: publication
- By this: publisher
- In this Subject: Dermatology
- By this author:
Bari, YS
;
Yildiz, L
;
entürk, N
;
Kandemr, B
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