Evaluation of nitrosative and oxidative stress in Behçet disease

Authors: Bekpinar, S¹; Kiliç, N¹; Ünlüçerçi, Y; Akdag-Köse, A²; Azizlerli, G²; Özbek-Kir, Z¹

Source: Journal of the European Academy of Dermatology & Venereology, Volume 19, Number 2, March 2005 , pp. 167-171(5)

Publisher: Wiley-Blackwell

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Abstract:

Plasma nitrotyrosine and nitrite/nitrate levels as markers of nitrosative stress and plasma malondialdehyde (MDA) and protein carbonyl as markers of oxidative stress were determined in patients with Behçet disease (BD). To evaluate the balance between oxidant and antioxidant systems in these patients, we measured erythrocyte lysate CuZn superoxide dismutase (CuZn SOD) activity, plasma sulfhydryl (SH) values and total antioxidant activity. We also determined levels of plasma C-reactive protein (CRP), a key marker of inflammation, and compared them with those of healthy subjects. We found plasma nitrotyrosine levels of BD patients to be increased, indicating that nitrosative stress may occur in these patients. Plasma MDA and CRP levels in BD patients were found to be significantly higher than those in control group. However, plasma SH levels were decreased. No changes were observed in the other measured parameters of the patient group compared with the controls. These data suggest the possible involvement of nitric oxide (NO) together with reactive oxygen substances (ROS) in the pathogenesis of BD.

Keywords: Behçet disease; nitrosative stress; oxidative stress

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1468-3083.2005.01075.x

Affiliations: 1: Biochemistry and 2: Dermatology, Istanbul Faculty of Medicine, Istanbul University, Çapa 34093-Istanbul, Turkey.

Publication date: 2005-03-01