IngentaConnect An evaluation of the change in electrocardiographic P-wave variab...

Authors: Caron, M. F.¹; Song, J.¹; Ammar, R.¹; Kluger, J.²; White, C. M.¹

Source: Journal of Clinical Pharmacy & Therapeutics, Volume 26, Number 2, April 2001 , pp. 145-148(4)

Abstract:

Background: Caffeine's effect on supraventricular dysrhythmias is poorly understood, and establishing a marker to predict atrial fibrillation may help to explain supraventricular dysrhythmias caused by caffeine.

Objective: To evaluate the effects of caffeine (mean 6·1 mg/kg) on maximum P-wave duration and P-wave dispersion in normal volunteers.

Method: A randomised, double-blind, placebo-controlled, crossover study in 10 healthy volunteers at least 17 years of age at the University of Connecticut. Participants abstained from caffeinated products for at least 2 days before study initiation and were randomly allocated on different days to receive placebo or caffeine 400 mg. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG was performed 3 h after ingesting the study drug.

Results: No significant changes were found within intra- or intergroup comparisons for any P-wave variables measured.

Conclusions: Single dose caffeine (400 mg) does not affect average P-wave duration, maximum P-wave duration or P-wave dispersion in normal individuals.

Keywords: atrial fibrillation; caffeine; p-wave; variables

Document Type: Research article

DOI: 10.1046/j.1365-2710.2001.00336.x

Affiliations: 1: University of Connecticut School of Pharmacy, Storrs and Farmington, CT, U.S.A. 2: University of Connecticut School of Medicine, Storrs and Farmington, CT, U.S.A.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax Refund Policy

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers