The effect of paroxetine on thiothixene pharmacokinetics

Authors: Guthrie, S. K.¹; Hariharan, M.²; Kumar, A. A.¹; Bader, G.²; Tandon, R.²

Source: Journal of Clinical Pharmacy & Therapeutics, Volume 22, Number 3, June 1997 , pp. 221-226(6)

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Abstract:

Objective: In this study healthy volunteers received thiothixene with and without a 3-day pretreatment with paroxetine to determine if paroxetine decreased the clearance of thiothixene.Method: Ten healthy medication-free volunteers (4 women and 6 men, mean age 38±12 years) were randomized to receive a single 20 mg oral dose of thiothixene on two separate occasions. On one occasion thiothixene was given concurrently, and following 3 days of pre-treatment with oral paroxetine (20 mg/day). On the other occasion thiothixene was given without paroxetine pre-treatment. The two study days were separated by a minimum period of 2 weeks. On both study days, after the administration of thiothixene, 10 ml blood samples were collected over the next 72 h.Results: None of the pharmacokinetic parameters of thiothixene were significantly altered by a 3-day treatment with paroxetine.Discussion: It is likely that the CYP2D6 isoenzyme is not responsible for a high proportion of thiothixene clearance, but one cannot exclude the possibility that a longer paroxetine pretreatment might have caused some inhibition of thiothixene clearance.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2710.1997.95175951.x

Affiliations: 1: College of Pharmacy, The University of Michigan, 2: Department of Psychiatry, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.

Publication date: 1997-06-01