Authors: Leong S.; Docherty J.R.

Source: Journal of Autonomic Pharmacology, Volume 21, Number 2, 1 April 2001 , pp. 95-99(5)

Publisher: Wiley-Blackwell

Abstract:

1 We have examined the effects of 17-oestradiol on spontaneous spikes and contractions to noradrenaline in rat portal vein.

2 The 17-oestradiol (10 M) significantly reduced the maximum height of spontaneous spike contractions and significantly reduced the maximum contraction to noradrenaline (10 M) in portal vein from both male and female rats.

3 The protein synthesis inhibitor cycloheximide (10 M) did not significantly affect the inhibitory actions of 17-oestradiol (10 M) against spontaneous spike contractions and contractions to noradrenaline.

4 In summary, 17-oestradiol diminishes spontaneous spike contractions and the contractile response to noradrenaline in rat portal vein, by a non-genomic action.

Keywords: oestrogen; 17-oestradiol; portal vein; vascular smooth muscle

Document Type: Research article

Publication date: 2001-04-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Leong S. ;  Docherty J.R.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers