Modulation of M-channel conductance by adenosine 5 triphosphate in bullfrog sympathetic B-neurones

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By this: publisher
In this Subject: Pharmacology
By this author: Chen H. ;&nbsp; Kurennyi D.E. ;&nbsp; Smith P.A.

Authors: Chen H.; Kurennyi D.E.; Smith P.A.

Source: Journal of Autonomic Pharmacology, Volume 21, Number 1, February 2001 , pp. 57-62(6)

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Abstract:

1 Adenosine 5 prime triphosphate (ATP) (0.5–500 M) or muscarine (0.1–1.0 M) suppressed M-current/conductance (I_M/g_M) in B-cells of bullfrog sympathetic ganglion. Both agonists suppressed steady-state M-conductance (g_M) at –30 mV and there was either no change or a slight increase in the time constants for g_M activation ( tgr _a at –30 mV) and deactivation ( tgr _d at –50 mV).

2 It has previously been shown that experimental elevation of intracellular Ca²⁺ concentration ([Ca²⁺]_i) suppresses g_M and this is associated with decreases in both tgr _a and tgr _d. As these changes in kinetics differ from those we observe with agonist application, our results cast doubt on the hypothesis that elevation of [Ca²⁺]_i is involved in the transduction mechanism for ATP- or muscarine-induced g_M suppression.