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Pressure modulates the reactivity of isolated rabbit epicardial arteries

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1 The magnitude of responses to prostaglandin F (PGF) and adenosine (ADO) in pressurized rabbit epicardial coronary arteries (367 ± 44 μm o.d.) with intact endothelium was assessed when they developed spontaneous tone.

2 The arteries were cannulated and changes in arterial diameter registered with an automated video perfusion system. The vessels, in the stabilization period at 60 mmHg, were divided into two groups, one exposed to a longitudinal stretch of +20% of unstretched initial length (Lo), and the other to +35% Lo, which developed spontaneous tone. In both cases, diameter–pressure curves were obtained by changing the intravascular pressure from 30 to 120 mmHg in aleatory steps of 30 mmHg (dp/dt = 15 mmHg s−1).

3 Diameter reduction of the arteries with stretch of +35% Lo in response to 1 μmPGF was greater than that with stretch of +20% Lo. Likewise, increase of the arteries that had +35% Lo in response to 1 μmADO was greater than with +20% Lo.

4 Intravascular flow (40 μl min−1) increased the tone level of arteries. The addition of PGF enhanced this tone which was similar to that obtained with a stretch of +35% Lo and no flow, whereas the effect of ADO was increased.

5 These data indicate that the vasomotor responses of PGF and ADO are modulated by the degree of longitudinal stretch in epicardial arteries.
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Document Type: Original Article

Affiliations: Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo, 4; 28029 Madrid, Spain

Publication date: 01 October 1997

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