Pharmacological characterization of adrenoceptors in horse corpus cavernosum penis

Authors: Recio, P.; López, P. G.; Fernández, J. L. G.; García-Sacristán, A.

Source: Journal of Autonomic Pharmacology, Volume 17, Number 3, June 1997 , pp. 191-197(7)

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

1 The presence and types of α and β-adrenoceptors in the corpus cavernosum of the horse were studied in vitro by using selected ligands of adrenoceptors and isometric tension recording.

2 Noradrenaline and phenylephrine induced concentration-dependent contractions in corpus cavernosum preparations. B-HT 920 had no effect.

3 Phentolamine and prazosin produced a shift to the right of the dose-response curve of noradrenaline, while the α₂-antagonist, rauwolscine had no effect on the response to noradrenaline. Phenylephrine-evoked contractions of corporal strips were significantly inhibited by the α₁-adrenoceptor antagonist, prazosin.

4 Isoprenaline and salbutamol each relaxed precontracted corpus cavernosum preparations in a concentration-dependent manner; the isoprenaline effect was blocked by propranolol, practolol and butoxamine. The salbutamol effect was blocked by butoxamine.

5 These results suggest the presence of postjunctional α₁-adrenoceptors in horse corpus cavernosum. There is also a heterogenous population of β-adrenoceptors in this tissue, belonging to the β₁ and β₂ subtypes.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2680.1997.00457.x

Affiliations: 1: Departamento de Fisiología, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain

Publication date: 1997-06-01