Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum

Authors: Velasco, A.¹; Maroto, M.¹; Dueñas, A.¹; Carvajal, A.¹; Fernández de la Gándara, F.²; Nieto, A.²

Source: Journal of Autonomic Pharmacology, Volume 17, Number 1, February 1997 , pp. 53-57(5)

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Abstract:

1 4-Aminopyridine and 3,4-diaminopyridine produced concentration-dependent contraction on guinea-pig isolated ileum incubated in Tyrode solution. The EC₅₀ values were 1.14 × 10⁻⁴ and 1.39 × 10⁻⁴M, respectively.

2 Calcium channel blockers such as verapamil, diltiazem, nifedipine, flunarizine, and lanthanum chloride antagonized the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum.

3 Diazoxide and atropine sulphate behaved similarly as antagonists of the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum.

4 It is concluded that the aminopyridines exert their effects through the release of acetylcholine from parasympathetic nerve terminals.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2680.1997.00441.x

Affiliations: 1: Department of Pharmacology, Faculty of Medicine, Avda. Ramón y Cajal N° 7, E-47005 Valladolid, Spain, 2: Department of Surgery, Faculty of Medicine, Avda. Ramón y Cajal N° 7, E-47005 Valladolid, Spain

Publication date: 1997-02-01