Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts

Authors: Lemar, K.M.; Turner, M.P.; Lloyd, D.

Source: Journal of Applied Microbiology, Volume 93, Number 3, September 2002 , pp. 398-405(8)

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Abstract:

k.m. lemar, m.p. turner and d. lloyd. 2002.

Aims: To determine the effects of fresh and freeze-dried extracts of Allium sativum on the physiology and morphology of Candida albicans.

Methods and Results: Inhibition of growth in glucose-yeast extract-peptone was measured using a multiwell plate reader. Scanning and transmission electron microscopy investigations indicated loss of structural integrity. Gas chromatography-mass spectrometry of extracts was employed to separate and quantify putative inhibitory sulphur-containing components.

Conclusions: Fresh garlic extract has a greater efficacy than garlic powder extract as indicated both by its effects on morphology and inhibition of growth.

Significance and Impact of the Study: The ubiquitous opportunistic pathogen C. albicans is sensitive to garlic; resistance to the broad spectrum of active principles present is unlikely so that its anticandidal effects may provide an important alternative route to chemotherapy.

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2672.2002.01707.x

Affiliations: 1: Microbiology (BIOSI 1), Cardiff University, Cardiff, Wales, UK

Publication date: 2002-09-01