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Drug‐Ceramic 2‐Dimensional Nanoassemblies for Drug Delivery System in Physiological Condition

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Abstract:

The anticancer drug methotrexate (MTX) was successfully incorporated into the layered ceramic nanoparticles of layered double hydroxides (LDHs). The prepared MTXLDH two‐dimensional nanoassemblies showed enhanced chemical and thermal stability of intercalated MTX molecules through the effective electrostatic interaction with ceramic LDH layers. And the surface charge of MTXLDHs was determined to be highly positive whereas that of MTX is fairly negative. The anticancer effect of MTXLDH compared with MTX was evaluated in the human osteosarcoma cell culture line SaOS‐2, showing much faster drug efficacy with low concentration. The time‐dependent cellular uptake of MTX determined by high performance liquid chromatography showed the much enhanced cellular drug concentration of MTXLDH treated cancer cells than the MTX treated ones. The particle size of MTXLDH nanoassemblies was estimated in various solutions such as saline, phosphate saline, and RPMI 1640 cell culture medium, showing that the hydrodynamic size maintains at ~100 nm, regardless of the suspension media. The positive surface charge and ~100 nm size of MTXLDHs is considered to be the major factor in the high cellular uptake and enhanced drug efficacy.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1551-2916.2012.05219.x

Publication date: September 1, 2012

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