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Nanostructured Forsterite Coating Strengthens Porous Hydroxyapatite for Bone Tissue Engineering

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Abstract:

Many attempts have been focused on preparing highly porous scaffolds with appropriate mechanical strength. This paper has developed a new route to enhance the compressive strength of porous hydroxyapatite (HA) scaffold (porosity: ∼83%, mean pore size: ∼740 m). Briefly, this route included a nanostructure coating of forsterite (Mg2SiO4) on struts of porous HA. The coating microstructure consisted of the grains with the range between 35 and 80 nm and nanosize pores that could be detected by scanning electron microscopy observation. This simple method improved the compressive strength of highly porous HA from 0.12 to 1.61 MPa. The scaffolds obtained provided a good mechanical support while maintaining bioactivity, and hence they could be used as tissue engineering scaffolds for low-load-bearing applications.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1551-2916.2010.03817.x

Affiliations: Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran

Publication date: September 1, 2010

bsc/jace/2010/00000093/00000009/art00060
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