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In Vitro Bioactive Characteristics of Borate-Based Glasses with Controllable Degradation Behavior

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Abstract:

Silicate-based bioactive glasses undergo incomplete conversion to a calcium phosphate material after in vivo implantation, which severely limits their biomedical application. In this communication, novel borate-based glasses with controllable degradation behavior were developed and their bioactive potential was investigated in vitro. When immersed in a 0.02M K2HPO4 solution at 37°C, these glasses reacted to form a carbonate-substituted hydroxyapatite (c-HA) on their surfaces, indicating their bioactive potential. The conversion rate to c-HA was controlled by adjusting the B2O3/SiO2 ratio in the glass composition. The results indicate the potential application of the borate-based bioactive glass as scaffold materials for bone tissue engineering.

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1551-2916.2006.01358.x

Affiliations: 1: Institute of Bioengineering & Information Technology Materials, Tongji University, Shanghai 200092, China 2: Department of Materials of Science and Engineering, University of Missouri–Rolla, Rolla, Missouri 65409 3: Graduate Center for Materials Research, University of Missouri–Rolla, Rolla, Missouri 65409

Publication date: 2007-01-01

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