Skip to main content

Enzymatic Preparation of Hollow Yttrium Oxide Microspheres for In Situ Radiotherapy of Deep-Seated Cancer

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Chemically durable microspheres 20−30 m in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer, as they can be activated by neutron bombardment to form -emitters, and can be injected into the vicinity of the cancer cells to impart a large localized dose of -radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, and the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1551-2916.2005.00867.x

Affiliations: 1: Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan 2: Institute of Science and Technology Research, Chubu University, Aichi 487-8501, Japan 3: Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

Publication date: April 1, 2006

bsc/jace/2006/00000089/00000004/art00027
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more