Skip to main content

Enzymatic Preparation of Hollow Yttrium Oxide Microspheres for In Situ Radiotherapy of Deep-Seated Cancer

Buy Article:

$51.00 plus tax (Refund Policy)


Chemically durable microspheres 20−30 m in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer, as they can be activated by neutron bombardment to form -emitters, and can be injected into the vicinity of the cancer cells to impart a large localized dose of -radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, and the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.

Document Type: Research Article


Affiliations: 1: Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan 2: Institute of Science and Technology Research, Chubu University, Aichi 487-8501, Japan 3: Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

Publication date: April 1, 2006


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more