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Enzymatic Preparation of Hollow Yttrium Oxide Microspheres for In Situ Radiotherapy of Deep-Seated Cancer

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Chemically durable microspheres 20−30 m in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer, as they can be activated by neutron bombardment to form -emitters, and can be injected into the vicinity of the cancer cells to impart a large localized dose of -radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, and the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.

Document Type: Research Article


Affiliations: 1: Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan 2: Institute of Science and Technology Research, Chubu University, Aichi 487-8501, Japan 3: Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

Publication date: April 1, 2006


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