Authors: Alexander, Ivy M.; Moore, Anne

Source: Journal of the American Academy of Nurse Practitioners, Volume 19, Number 3, March 2007 , pp. 152-163(12)

Publisher: Wiley-Blackwell

Abstract:

Purpose:

This article reviews the pathophysiology of vasomotor symptoms (VMS) of menopause and current management options. Data sources:

Current scientific literature. Conclusions:

In most menopausal women, loss of ovarian function results in VMS, including hot flashes, night sweats, and mood and sleep disturbances. Hormone therapy (HT) has been the mainstay of VMS treatment for many years, but safety concerns raised by publication of the Women's Health Initiative (WHI) results have dramatically reduced the use of this treatment. Since the WHI published its findings, attention has focused on other novel treatments for menopausal symptoms, including low-dose oral or transdermal HT and agents such as selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, gabapentin, and clonidine. Many women also use complementary and alternative medications to manage VMS, but little evidence from controlled clinical trials supports their efficacy. Implications for practice:

The increasing number of alternative treatments for VMS requires improvement in patient-provider communication about treatment risks and benefits, individualization of treatment to meet patient needs and attitudes, and careful follow-up to ensure adherence to potentially effective therapy. Nurse practitioners play a leading role in patient evaluation, discussions, and management to help women achieve control over bothersome VMS that dramatically impact their quality of life.

Keywords: Vasomotor symptoms; norepinephrine; serotonin; pharmacotherapy; nonhormonal; complementary; alternative

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1745-7599.2006.00206.x

Affiliations: 1: Vanderbilt University School of Nursing, Nashville, Tennessee

Publication date: 2007-03-01

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