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Haemolytic‐uraemic syndrome during severe lupus nephritis: efficacy of plasma exchange

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Abstract:

Abstract

Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic‐uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was successfully treated with steroids, cyclophosphamide and especially plasma exchange with plasma replacement. This report highlights the importance of recognising atypical HUS in SLE patients by looking for schistocytes in case of haemolytic anemia with a negative antiglobulin test, in order to begin plasma exchange.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2011.02591.x

Affiliations: 1: Department of Internal Medicine and Clinical Immunology 2: Faculty of Medicine and Pharmacy, CR INSERM 866, Lipids Nutrition Cancer, University of Burgundy, Dijon, France

Publication date: January 1, 2012

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