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Reversible posterior leukoencephalopathy syndrome: diagnosis and management in the setting of lung transplantation

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Reversible posterior leukoencephalopathy syndrome (RPLS) is a potentially devastating early complication of calcineurin inhibitor (CNI) therapy in solid organ transplantation. Management centres on cessation of CNI therapy; however, this strategy is complicated in lung transplantation because of the threat of allograft rejection, or, if CNI is replaced with mammalian target of rapamycin-based immunosuppression, poor wound healing and bronchial dehiscence. We describe four cases of RPLS after lung transplantation, emphasizing the diagnostic and management approach required to maintain a healthy allograft and ensure that RPLS is, as the name suggests, reversible.

Keywords: cyclosporine; immunosuppressive agents; lung transplantation; posterior leukoencephalopathy syndrome; tacrolimus

Document Type: Research Article


Publication date: October 1, 2010

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