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Prognostic value of trisomy 8 in primary myelodysplastic syndrome

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Abstract:

Background:  According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be categorized into poor risk cytogenetic group. The aim of this study was to clarify the prognostic role of +8 in MDS patients by comparing patients with normal karyotype, 20q‐ and ‐7/7q‐.

Keywords: cytogenetics; myelodysplastic syndrome; prognosis

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1445-5994.2009.02061.x

Affiliations: Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China

Publication date: 2010-10-01

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