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Prognostic value of trisomy 8 in primary myelodysplastic syndrome

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Abstract:

Abstract Background: 

According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be categorized into poor risk cytogenetic group. The aim of this study was to clarify the prognostic role of +8 in MDS patients by comparing patients with normal karyotype, 20q- and -7/7q-. Methods: 

The consecutive samples of 435 MDS patients in Shanghai were collected by prospective methods and diagnosed according to World Health Organization classification. Cytogenetic analysis was performed using conventional G-banding karyotyping and fluorescence in situ hybridization techniques. Prognosis was estimated by univariate Log-rank method and multivariate Cox proportional hazard models. Results: 

Of 424 cases completing the cytogenetic analysis, 71 (16.7%) had +8, including 38 patients with sole +8 (9.0%). No significant difference in median survival was observed between patients with sole +8 and that with +8 and one of other abnormalities. The +8 clone size was not linked to survival. The median survival of patients with +8, normal karyotype and complex karyotype was 25 months, 38.1 months and 5.9 months respectively. However, no significant difference was observed between patients with 20q- (21.4 months) and -7/7q- (25.8 months). Trisomy 8 was an independent prognostic factor by Cox regression model. Conclusion: 

There is no significant difference in prognosis between patients with +8 and patients with 20q- or -7/7q-. Trisomy 8, 20q- and -7/7q- are categorized as intermediate cytogenetic risk according to our primary study.

Keywords: cytogenetics; myelodysplastic syndrome; prognosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2009.02061.x

Publication date: October 1, 2010

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