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Carbimazole‐induced agranulocytosis: does antineutrophil cytoplasmic antibody have a role?

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Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 weeks after commencement of carbimazole for Graves' disease. It may give credence to the theory that implicates antineutrophil cytoplasmic antibodies in the pathogenesis of agranulocytosis induced by antithyroid drugs.
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Keywords: Graves' disease; agranulocytosis; antineutrophil cytoplasmic antibody; autoantibody; carbimazole; pyoderma gangrenosum

Document Type: Research Article

Affiliations: 1: Department of Medicine 2: Endocrine Centre and 3: Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Victoria, Australia

Publication date: 01 April 2010

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