Reversible posterior encephalopathy syndrome associated with bortezomib

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Reversible posterior encephalopathy (RPES) is an uncommon neurological syndrome that is being increasingly reported in association with anti-neoplastic therapies. The first case of reversible posterior encephalopathy associated with the proteosome inhibitor bortezomib is described and the reported experience of the occurrence of RPES with other antineoplastic therapies reviewed. Dysregulation of cerebral vasomotor autoregulation is postulated as the underlying pathophysiology in this case of bortezomib associated RPES.

Keywords: bortezomib; proteosome inhibitor; reversible posterior encephalopathy

Document Type: Research Article


Affiliations: Departments of Haematology and

Publication date: January 1, 2010

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