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Malignant fibrous histiocytoma complicating nephrogenic systemic fibrosis post liver transplantation

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A 46-year-old man with cirrhosis secondary to hepatitis C virus infection and alcohol underwent orthotopic liver transplantation, which required urgent re-grafting because of biliary sepsis from necrosis of the left liver lobe. Recovery was complicated by renal failure and nephrogenic systemic fibrosis (probably related to intravenous gadolinium exposure). He subsequently developed a malignant fibrous histiocytoma. We present this case highlighting the occurrence of two rare conditions in the same patient following liver transplantation. We believe this is the first case of its kind to be reported.
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Keywords: histiocytoma; liver transplantation; systemic fibrosis

Document Type: Research Article

Affiliations: 1: Western Australian Liver Transplantation Service, 2: Department of Nephrology, Sir Charles Gairdner Hospital, 3: Division of Tissue Pathology, PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, and

Publication date: 2009-09-01

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