Skip to main content

Search for pathogenetic variants of the SPRY2 gene in intestinal innervation defects

Buy Article:

$43.00 plus tax (Refund Policy)


SPRY2 is an inducible inhibitor of signalling mediated by tyrosine kinases receptors, whose targeting causes intestinal hyperganglionosis in mice. In this light, we have undertaken a mutational analysis of the SPRY2 gene in patients affected with intestinal neuronal dysplasia (IND), without detecting nucleotide changes in any of the 26 DNA samples analysed, with the exception of two already known polymorphic variants. A role of the SPRY2 gene in IND pathogenesis can be thus excluded.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: SPRY2; intestinal neuronal dysplasia; mutation screening

Document Type: Research Article

Affiliations: 1: Laboratory on Pathophysiology of Uremia and 2: Department of Pediatric Surgery, G. Gaslini Institute, 3: Laboratory of Molecular Genetics, 4: Paediatric Surgery Department, Policlinico San Matteo, Pavia, Italy

Publication date: 2009-05-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more