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Kimura disease: review of the literature

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Kimura disease (KD) is a rare, chronic inflammatory disease of unknown cause and is characterized by painless s.c. swellings and lymphadenopathy commonly affecting the head and neck region. Much therapeutics has been used to treat KD, but is not satisfactory because of frequent relapse. Imatinib has been reported previously to be useful for treatment of hypereosinophilic syndrome and may work by selectively blocking protein-tyrosine kinases, such as platelet-derived growth factor receptor, and c-Kit. We carried out immunohistochemical examination of platelet-derived growth factor receptor-α and c-Kit in tissues from patients with KD. The results were positive and suggested that Imatinib might be an effective drug for the treatment of the disease. We have also briefly reviewed the epidemiology, aetiology, clinical manifestations, laboratory and pathological examinations, differential diagnoses, treatment and prognosis of KD in this manuscript.

Keywords: Imatinib; Kimura disease; eosinophilia; immunohistochemistry; protein-tyrosine kinase

Document Type: Research Article


Affiliations: 1: Beijing Di-tan Hospital, Beijing, China 2: Pathology 3: Departments of Infectious Diseases 4: Nephrology 5: Surgery, The Third Affiliated Hospital to Wenzhou Medical College, Wenzhou, Zhejiang

Publication date: August 1, 2008


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