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Guidelines for the prevention of sepsis in asplenic and hyposplenic patients

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Asplenic or hyposplenic patients are at risk of fulminant sepsis. This entity has a mortality of up to 50%. The spectrum of causative organisms is evolving as are recommended preventive strategies, which include education, prophylactic and standby antibiotics, preventive immunizations, optimal antimalarial advice when visiting endemic countries and early management of animal bites. However, there is evidence that adherence to these strategies is poor. Consensus-updated guidelines have been developed to help Australian and New Zealand clinicians and patients in the prevention of sepsis in asplenic and hyposplenic patients.
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Keywords: antibiotics; asplenia; hyposplenia; immunization; spleen

Document Type: Research Article

Affiliations: 1: Infectious Diseases Unit, Murdoch Children’s Research Institute 2: Department of Microbiology and Infectious Diseases, Royal Children’s Hospital 3: Infectious Diseases Unit, Royal Melbourne Hospital 4: Children’s Hospital 5: Sydney Adventist Hospital 6: Department of Microbiology, Auckland City Hospital, Auckland, New Zealand 7: Infectious Diseases Unit, University of NSW, Prince of Wales Hospital, Sydney, New South Wales 8: Infectious Diseases Unit, Canberra Hospital, Canberra, Australian Capital Territory 9: Department of lnfectious Diseases and Microbiology, Royal Hobart Hospital, Hobart, Tasmania, Australia 10: Haematology Unit, Alfred Hospital

Publication date: 2008-05-01

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