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Consensus guidelines for ‘rainy day’ autologous stem cell harvests in New South Wales

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Abstract:

Abstract

Autologous stem cell transplantation (ASCT) has a well-established role in the treatment of haematological malignancies. Stem cells are commonly collected following salvage chemotherapy although there may be advantages in collecting earlier in the disease course. A ’rainy day’ harvest (RDH) refers to the collection of autologous haemopoietic stem cells for long-term storage. Although there are few data to support RDH, there is increasing evidence that such harvests are being carried out, creating storage pressures in stem cell laboratories across New South Wales. The Bone Marrow Transplant Network New South Wales conducted a three-staged exercise to develop consensus-based RDH guidelines. Using available evidence, guidelines were developed supporting RDH for specific patients with acute and chronic myeloid leukaemias, follicular and other lymphomas, and multiple myeloma. Physician agreement with these disease-specific guidelines ranged between 58 and 100%. These consensus guidelines will improve equity of access to appropriate RDH and assist the planning of future storage requirements in New South Wales.

Keywords: autologous stem cell; cryopreservation; harvest; rainy day

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2008.01632.x

Affiliations: 1: Wollongong Hospital, Wollongong 2: Department of Haematology, Concord Hospital 3: Gosford Hospital, Gosford, New South Wales, Australia 4: Liverpool Hospital 5: Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital 6: BMT Network Secretariat, Sydney

Publication date: April 1, 2008

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