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Association between ulcerative colitis and multiple sclerosis

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Abstract

An association between inflammatory bowel disease (IBD) and multiple sclerosis (MS) has been described. The current study was undertaken to explore this association further. Personal records of patients with IBD and MS were reviewed. In addition, a search of medical records at a large tertiary teaching hospital in Sydney was carried out for the years 1996–2006. Four patients (three women and one man) with both ulcerative colitis and MS were identified. MS did not occur in any of our patients with Crohn’s disease. The association between ulcerative colitis and MS appears to be real and may help identify common factors involved in the cause of these two diseases. No association was found in this study between MS and Crohn’s disease, sparking consideration why such difference should occur. With the increasing use of biological therapies in IBD and their reported propensity to cause demyelination, recognition of an association is all the more important.
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Keywords: Crohn’s disease; anti-tumour necrosis factor; multiple sclerosis; ulcerative colitis

Document Type: Research Article

Affiliations: Department of Economics and Quantitative Methods, Westminster Business School, University of Westminster, London, UK

Publication date: 2007-10-01

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