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Angioedema, lymphoproliferative disorder and angiotensin-converting enzyme inhibitors: masking of diagnosis by corticosteroids

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Angioedema is a relatively common clinical disorder. Although most cases are idiopathic, the use of angiotensin-converting enzyme inhibitors is a well recognized cause of angioedema and a further rare but important diagnostic consideration is acquired C1 inhibitor deficiency. We discuss the diagnosis of C1 inhibitor deficiency in angioedema, with reference to a case in which the diagnosis was initially masked by the use of corticosteroids, which normalized the C1 inhibitor level.

Keywords: C1 esterase inhibitor; acquired angioedema; angiotensin-converting enzyme inhibitor; corticosteroid; low-grade lymphoproliferative disorder

Document Type: Research Article


Affiliations: 1: Divisions of Immunology and Allergy 2: Haematology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Publication date: September 1, 2007

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