If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Prognostic value of B-type natriuretic peptide in patients with chronic and advanced heart failure

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Abstract Background: 

An increase in circulating B-type natriuretic peptide (BNP) is associated with a poor outcome in patients with acute heart failure. The primary aim of this study was to investigate the prognostic value of BNP levels in patients with chronic and advanced heart failure. Methods: 

Fifty patients with New York Heart Association functional classes III and IV were enrolled in the study. Their blood BNP levels at admission were measured and patients were on follow up for 12 ± 2 months. Results: 

There was no significant correlation between BNP levels on admission and left ventricular ejection fraction (r = 0.12, P > 0.05). Twelve patients (24%) died during the follow up. BNP levels were lower in patients who died (501 ± 72 vs 877 ± 89 ng/L, P < 0.01). The logistic stepwise regression analysis showed that lower BNP level (<520 ng/L) on admission was an independent predictor of cardiovascular mortality in these patients (odds ratio 1.21, 95% confidence interval 1.06–2.32, P < 0.01). Conclusion: 

We conclude that patients with chronic and advanced heart failure have a lower circulating BNP level than those who survive. The paradoxically low BNP level is an adverse prognostic marker in advanced heart failure.

Keywords: B-type natriuretic peptide; heart failure; mortality; prognosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2006.01296.x

Affiliations: 1: School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia 2: Department of Cardiology, Renji Hospital, Medical School of Shanghai Jiaotong University, Shanghai, China

Publication date: March 1, 2007

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more