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Allogeneic bone marrow transplant for refractory mediastinal germ cell tumour: possible evidence of graft-versus-tumour effect

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Mediastinal germ cell tumours (GCT) carry a poor prognosis, particularly after relapse. We have reviewed the published reports of current treatments and describe a case with a cure after an allogeneic bone marrow transplant, which is not reported in the current published data. We believe that GCT may be susceptible to a graft-versus-tumour effect and suggest that patients with relapsed GCT be considered for allogeneic transplantation.

Keywords: allogeneic bone marrow transplant; graft-versus-tumour effect; relapsed extragonadal germ cell tumour

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2007.01244.x

Affiliations: 1: Westmead Hospital Medical Oncology Department, 2: Westmead Hospital Haematology Department, Westmead Hospital, Westmead, NSW, Australia

Publication date: February 1, 2007

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