Outcomes of patients with interstitial lung disease referred for lung transplant assessment

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Abstract:

Abstract Background:

Patients with interstitial lung disease (ILD) very frequently die before the opportunity to receive lung transplantation (LTx). This retrospective study describes the clinical course of 86 patients with ILD referred for LTx assessment between January 1999 and December 2002. Aims:

(i) To describe the outcomes, (ii) to identify reasons of delay to transplantation, (iii) to describe the causes of death/complications and (iv) to assess the pathological diagnosis and concordance with explanted lung pathology. Methods:

Data were collected from the case notes of all patients with ILD referred to the Alfred Hospital over a 4-year period. Results:

Twenty women and 66 men, mean age of 55 ± 8 years, were referred for LTx assessment. Forty-five patients were deemed not suitable for LTx and 41 were listed. Twenty-two patients underwent transplantation, 16 died on the waiting list and 7 are still on the waiting list. Complications were frequent (e.g. pulmonary embolism, malignancy and infection) and carried high mortality. Patients dying on the waiting list appeared generally to be in accelerated decline, dying shortly after listing, with no evidence in their lung function test assessment predicting them as a poor prognosis group. Conclusions:

Serious complications and death on the waiting list of patients with idiopathic pulmonary fibrosis are high, not apparently because of delayed referral but usually in patients undergoing very rapid decline.

Keywords: interstitial lung disease; lung transplantation; pulmonary fibrosis; usual interstitial pneumonia

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2006.01103.x

Affiliations: 1: Allergy, Immunology and Respiratory Medicine 2: Anatomical Pathology, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia

Publication date: July 1, 2006

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