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Profound lymphopenia and bacteraemia

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Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.

Keywords: B and T cell lymphopenia; bacteraemia; sepsis

Document Type: Research Article


Affiliations: Infectious Diseases, The Canberra Hospital

Publication date: 2006-06-01

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