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Management of metastatic gastrointestinal stromal tumour in the Glivec era: a practical case-based approach

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Gastrointestinal stromal tumour is now recognized as a distinct pathological malignancy and has received much attention over the last few years. Despite almost universal resistance to chemotherapy, a novel therapy, Imatinib, which targets the KIT receptor, has changed the natural history of this disease. We have audited the first 26 consecutive patients with gastrointestinal stromal tumour treated over 4 years at a single institution. A practical guide to the management of common toxicities and drug resistance is reported with a review of the published reports. Many of the strategies used are likely to be widely applicable to the use of targeted therapies in other malignancies.

Keywords: Imatinib; gastrointestinal stromal tumour; metastatic cancer; surgery; toxicity

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2006.01077.x

Affiliations: Department of Medical Oncology, Prince of Wales Hospital

Publication date: June 1, 2006

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